The Substance Use Prevention Coalition of Collin County began in 2005 as the Collin County Substance Abuse Coalition. The coalition was formed in response to a growing number of overdoses and deaths in Collin County due to heroin and methamphetamine use. The task force was comprised of various government and nonprofit agencies and organizations that included police, substance abuse groups, school counselors, and healthcare and treatment programs. The original mission of the coalition was to monitor and reduce the incidence of illness, injury and death among teenagers and young adults caused by substance abuse.
In 2017, the coalition changed their name to the Substance Use Prevention Coalition of Collin County. A few months later in 2018, the organization established its nonprofit status. Today, members come from all sectors of the community, including: parents, business communities, media, schools, law enforcement, faith-based organizations, civic and volunteer groups, health care professionals, organizations that serve youth or young adults, youth, young adults, state, local or tribal governmental agencies, other organizations involved in reducing substance abuse, and senior citizens.