Industrial operations face unique cybersecurity challenges: legacy assets, uptime requirements, and safety-critical processes. This session offers a practical roadmap for strengthening OT security by aligning business goals with common frameworks. We'll explore how defense-in-depth and strong asset management form the foundation for the protection of industrial automated control systems (IACS). Attendees will learn how to develop standards based security programs that turn raw OT data into actionable vulnerability insights. The session shares how IT-style response, backup & recovery, and governance adapt for OT without disrupting operations. Through real-world examples, participants will leave with a clear understanding of threat actor tactics-techniques-procedures (TTP's) and how to build a secure, resilient, and future-ready industrial cybersecurity program that reduces the likelihood of production downtime due to exploit and liability exposure. Expected Outcome: Understand how NIST CSF maps to IEC/ISA 62443 for OT, apply defense-in-depth and zones/conduits, operationalize asset inventory and risk-based remediation, and adopy monitoring, incident response and recovery that respect OT determinism and uptime. Intended Audience: This session will be ideal for OT/IT leaders, CIO, CISO, plant managers, controls & network engineers, security architects, and compliance/risk stakeholders seeking a practical roadmap to mature OT security programs.