Per- and polyfluoroalkyl substances (PFAS) are synthetic organic compounds that have been manufactured since the 1940s for use in non-stick coatings, waterproof fabrics and carpets, firefighting foams, food packaging, and many other applications. Human health and animal studies have linked PFAS exposure to negative health effects. PFAS have been detected in surface waters and fish across Wisconsin, and so the Department of Natural Resources (DNR) has embarked on a statewide monitoring effort to assess the scope of PFAS contamination. This presentation will discuss the results of this effort, including amounts of PFAS that were detected in surface waters (rivers, streams, inland lakes) and Lake Superior. We will also present data on PFAS detections in fish tissue and discuss fish consumption advisories related to one type of PFAS called perfluorooctane sulfonate (PFOS). Finally, this presentation will provide an update on DNR’s efforts to develop surface water quality standards PFAS.