As our environment becomes increasingly toxic, we need to harness the body’s innate ability to mobilise and clear toxins. We now know that includes peripheral circadian clocks in organs such as the gut, liver, pancreas and microbiome that link to the central brain clock and influence detoxification. Interestingly, time of day influences how polyaromatic hydrocarbons from charred meat are metabolised and how toxic they are; and clock proteins regulate the CYP450 enzymes, influencing the best time of day to take medications. Join nutritional biochemist Dr Rhona Creegan as she details these clock mechanisms, providing clinical tips on how to repair them to improve our patients’ detoxification capacity.