In an age where hustle culture and the demands of modern life often override the importance of eating and sleeping in accordance with our biological clock, the detrimental effects of circadian disruption are becoming increasingly apparent. Mounting evidence indicates that this misalignment increases the risk of chronic disease, such as diabetes, hypertension, and cancer. Type 2 diabetes makes up approximately 95% of all diabetes cases, and its rapidly growing prevalence is largely attributed to lifestyle factors, such as physical inactivity, smoking, and poor dietary choices. However, research suggests that an additional modern-day lifestyle factor, circadian disruption, is emerging as a major contributing factor to type 2 diabetes development. Shift work alone is correlated with a 10-40% increased risk of type 2 diabetes. While healthcare practitioner-guided lifestyle interventions may be sufficient to prevent and sometimes even reverse lifestyle diseases, sustained remission is more complex and difficult to achieve. This presentation will explore the intricate mechanisms linking circadian disruption and glucose metabolism, and strategies to sync circadian rhythms for enhanced and lasting metabolic health. Gain valuable insights into: • Which key factors contribute to circadian misalignment • How circadian disruption impacts glucose control and diabetes development • Innovative natural medicines which target the circadian system and promote metabolic health • How feeding patterns influence circadian rhythms, and how to utilise them to improve glucose metabolism