Breast milk-origin probiotics offer a powerful intersection of science, evidence, and clinical practice. Regarded as “the new kids on the block” these specialised probiotics, distinct from those found in the normal bowel, possess unique properties. From pre-conception, through infancy and every life stage to adulthood, they play a crucial role in health and well-being. In this presentation, we delve into the extensive body of evidence supporting their use, explore their distinctive features and mechanisms of action and discuss their applications in clinical practice across various life stages and conditions, including case studies.