This talk is designed to give an introduction to some uncommon species seen in laboratory animal medicine. The talk focuses on model information, care and diseases of the unique animals. Major emphasis is placed upon spontaneous diseases arising in these species. Animal models to be discussed include: Electric eels, tentacled snakes, galagos (bush babies), Xenopus laevis, zebra finches, Grasshopper Mice (Onychmys torridus), terrestrial frogs, naked mole rats (Heterocephalus glaber), etc…