The use of ferrets as an animal model in virology with a focus on virus transmission studies
The ferret belongs to the family of mustelids (weasels) and the infection of ferrets with influenza viruses has been described as early as 1933. To this day, the ferret remains an important animal model to mimic human infection by several respiratory viruses including influenza viruses, coronaviruses and Respiratory Syncytial Virus. An important feature of respiratory viruses is their ability to transmit via the air between individuals. This key aspect can be studied in custom designed ‘airborne transmission settings’ equipped with ferrets as virus donors and recipients. General aspects, advantages and limitations of the ferret in virological research will be discussed.