Pre-clinical physiology studies in large animal models are essential to bridge the translational research gap between small animals and clinical studies. CHI has a long track-record of studying sheep as large animal models of cardiovascular disease. We have modelled normal physiology, acute myocardial infarction and congestive heart failure. Whilst CVRI Singapore has established pig models, we now plan to introduce sheep to complement our research. Sheep are relatively easy to handle and house long term. Their size is comparable to small adults and thus they are amenable to serial blood sampling for multiple biomarkers, instrumentation with widely available clinical equipment and monitoring devices.