Whole Genome Sequencing (WGS) and Next Generation Sequencing (NGS) have revolutionized food safety—moving beyond the research lab to become essential tools in public health surveillance and outbreak response. This session will explore how these technologies have redefined how we detect, investigate, and prevent foodborne illness, providing unmatched precision in tracking contamination sources and microbial transmission pathways. Attendees will gain insights into how WGS is being applied not just by regulators, but also by food manufacturers and public health professionals to enhance traceability, validate preventive controls, and even protect brand integrity during investigations. From early detection to exoneration, this session will unpack the critical role genomic tools play in a modern, science-driven food safety system.